Extrapituitary action of gonadotropin-releasing hormone: direct inhibition ovarian steroidogenesis
Hsueh, A.J.; Erickson, G.F.
Science 204(4395): 854-855
1979
ISSN/ISBN: 0036-8075 PMID: 375393 Document Number: 142843
Gonadotropin-releasing hormone (GnRH) and its agonistic analogs inhibited the follicle-stimulating hormone (FSH)-induced increase of estrogen and progesterone production in vitro by rat ovarian granulosa cells. Likewise, GnRH analogs inhibited FSH-induced changes in ovarian function is hypophysectomized rats in vivo. GnRH, in addition to its well-known gonadotropin-releasing action in the pituitary, exerts a direct inhibition of ovarian steroidogenesis.
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