Natural oestrogen in the female climacteric--influence on blood coagulation and fibrinolysis
Lagrelius, A.; Lunell, N.O.; Blombäck, M.
Thrombosis and Haemostasis 40(3): 532-541
1979
ISSN/ISBN: 0340-6245 PMID: 154749 Document Number: 142774
The effect on blood coagulation and fibrinolysis of a natural estrogen preparation, piperazine estrone sulfate, prospectively in menopausal women was investigated. Scopolamine was given to the control group. The women were investigated before and during treatment with regard to factors VIII, VII, X, V, fibrinopeptide A, antithrombin III, plasminogen, rapid antiplasmin and .alpha.1-antitrypsin. There was no significant change towards hypercoagulability or decreased fibrinolysis in any group. In the estrogen group a tendency towards an increased level of plasminogen and a decreased level of antiplasmin was demonstrated. In the scopolamine group there was an unexpected fall in factors X and V and also in plasminogen and .alpha.1-antitrypsin. A low level of some blood coagulation factors in some of the women before treatment was somewhat astonishing. None had any history of excessive bleeding.