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Ventilation-perfusion and gas exchange effects of sodium nitroprusside in dogs with normal and edematous lungs

Colley, P.S.; Cheney, F.W.; Hlastala, M.P.

Anesthesiology 50(6): 489-495

1979

ISSN/ISBN: 0003-3022
PMID: 453574
Document Number: 142061
The mechanism by which sodium nitroprusside (SNP) decreases oxygenation was studied by determining its effects on venous admixture (.ovrhdot.QVA/.ovrhdot.Qt) and ventilation-perfusion distribution (.ovrhdot.VA/.ovrhdot.Q) in animals with normal and abnormal lungs. SNP was infused into 7 dogs anesthetized with pentobarbital. Mean blood pressure was decreased by 40% during normal lung function and again after the production of diffuse pulmonary edema by i.v. administration of oleic acid. Measurements of blood-gas values, .ovrhdot.QVA/.ovrhdot.Qt and .ovrhdot.VA/.ovrhdot.Q by the inert-gas-elimination method were taken before, during and after SNP infusion during ventilation with air and then during ventilation with 100% O2 in each pulmonary condition. SNP caused no change in cardiac output (.ovrhdot.Qt) during normal lung function or after the production of pulmonary edema. SNP had no effect on pulmonary gas exchange during normal lung function. During pulmonary edema and ventilation with air SNP decreased PaO2 (O2 partial pressure) from 71 .+-. 7 torr (mean .+-. 1 SD) to 61 .+-. 11 torr (P < .01) and increased .ovrhdot.QVA/.ovrhdot.Qt (O2 method) from 20 .+-. 8 to 38 .+-. 18% (P < .01). The increase in .ovrhdot.QVA/.ovrhdot.Qt correlated with a 28% decrease in pulmonary vascular resistance (PVR) (r, correlation coefficient = 0.863). During pulmonary edema with air and ventilation SNP increased .ovrhdot.VA/.ovrhdot.Q maldistribution but during ventilation with O2 SNP caused no significant change in .ovrhdot.Qs/.ovrhdot.Qt , PVR or .ovrhdot.VA/.ovrhdot.Q. The increase in .ovrhdot.QVA/.ovrhdot.Qt and increases in perfusion to low .ovrhdot.VA/.ovrhdot.Q regions are seen only in animals with pulmonary edema during ventilation with air. Apparently SNP impairs pulmonary gas exchange by inhibiting hypoxic vasoconstriction, thus increasing .ovrhdot.VA/.ovrhdot.Q maldistribution.

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Chang, C.L.; Yeh, F.C.; Ho, W.; Chen, H.I. 1985: Effects of sodium nitroprusside-induced hypotension on the cerebral and hindlimb blood flow in dogs Proceedings of the National Science Council Republic of China. Part B Life Sciences 9(3): 202-207
Koerner, S.K.; Vwith, F.J. 1974: Ventilation perfusion relationships between transplanted and emphysematous lungs Vascular Surgery 8(5): 283-297
Yamaguchi, K. 1989: Simultaneous analysis of the distribution of ventilation and diffusive conductance to perfusion in the lungs Nihon Kyobu Shikkan Gakkai Zasshi 27(12): 1407-1417
Ogasawara, H. 1996: Distribution of ventilation-perfusion ratios in paraquat-induced interstitial pneumonia in dogs Hokkaido Journal of Medical Science 71(2): 259-270
Mérillon, J.P.; Motte, G.; Leclerc, J.F.; Fruchaud, J.; Gourgon, R. 1977: Hemodynamic effects of sodium nitroprusside in the absence of coronary insufficiency Annales de Medecine Interne 128(6-7): 631-634
Schettini, A.; Moreshead, G. 1978: Effects of halothane and sodium thiopentone on surface brain pressure and brain electrical impedance in dogs with normal intracranial tension British Journal of Anaesthesia 50(10): 1003-1012
Bellotti, G.; Pileggi, F.; Galiano, N.; Camargo, P.R.; Ramires, J.A.; Checchi, E.; Ping, W.C.; Tranchesi, J.; Décourt, L.V. 1978: Hemodynamic and electrophysiological effects of sodium nitroprusside in patients with acute myocardial infarction Arquivos Brasileiros de Cardiologia 31(6): 359-367
Vanevskiĭ, V.L.; Mikhaĭlovich, V.A.; Ershova, T.G.; Kotomina, G.L. 1974: Effect of anesthesia with non-barbiturate preparations on gas exchange under conditions of normal ventilation and experimental hypoxia Vestnik Akademii Meditsinskikh Nauk SSSR 7: 56-62
Rabkin, S.W.; Ohmae, M.; Klass, D.J. 1982: Antiarrhythmic effects of cyclic guanosine 3' :5'-monophosphate and sodium nitroprusside on barium chloride arrhythmias in rabbits Archives Internationales de Pharmacodynamie et de Therapie 257(2): 225-238
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Keaney, N.P.; McDowall, D.G.; Turner, J.M.; Lane, J.R.; Okuda, Y. 1973: The effects of profound hypotension induced with sodium nitroprusside on cerebral blood flow and metabolism in the baboon British Journal of Anaesthesia 45(6): 639
Hecht, F.K.; Hakenbeck, H. 1990: Optimization of ventilation in anesthesia. 6. Quantitative registration of ventilation perfusion disorders during ventilation Anaesthesiologie und Reanimation 15(5): 305-309
Pande, J.N.; Bhasin, V.; Gupta, S.P.; Guleria, J.S. 1974: Effect of exercise on ventilation and gas exchange in normal subjects and in patients with chronic obstructive lung disease Indian Journal of Medical Research 62(3): 430-442
Hammon, J.W.; Wolfe, W.G.; Moran, J.F.; Jones, R.H.; Sabiston, D.C. 1976: The effect of positive end-expiratory pressure on regional ventilation and perfusion in the normal and injured primate lung Journal of Thoracic and Cardiovascular Surgery 72(5): 680-689
Dumont, L.; Lamoureux, C.; Lelorier, J.; Stanley, P.; Chartrand, C. 1983: Intravenous infusion of nitroprusside: effects upon cardiovascular dynamics and regional blood flow distribution in conscious dogs Archives Internationales de Pharmacodynamie et de Therapie 261(1): 109-121
Wilson, K.T.; Xie, Y.; Musch, M.W.; Chang, E.B. 1993: Sodium nitroprusside stimulates anion secretion and inhibits sodium chloride absorption in rat colon Journal of Pharmacology and Experimental Therapeutics 266(1): 224-230
Zäll, S.; Edén, E.; Winsö, I.; Volkmann, R.; Sollevi, A.; Ricksten, S.E. 1990: Controlled hypotension with adenosine or sodium nitroprusside during cerebral aneurysm surgery: effects on renal hemodynamics, excretory function, and renin release Anesthesia and Analgesia 71(6): 631-636
Nunn, P.P.; Myers, M.J.; Wang, Y.T.; Lavender, J.P.; Hughes, J.M. 1984: Effects of almitrine on the regional distribution of ventilation and perfusion in chronic bronchitis Bulletin Europeen de Physiopathologie Respiratoire 20(1): 37-42