Familial tubulopathy associating hypercalciuria and saline diabetes. Favorable results of indomethacin therapy
Bétend, B.; Chopard, P.; Monier, D.; Guibaud, P.; Hermier, M.; Larbre, F.; François, R.
Archives Francaises de Pediatrie 36(3): 258-267
1979
ISSN/ISBN: 0003-9764 PMID: 485770 Document Number: 140533
The association of hypercalciuria, salt losing renal disease, and a defect in urine concentrating ability with high renin and aldosterone levels is described in two brothers. One child had marked nephrocalcinosis by the age of 3 and the other severe growth retardation. In one child all the abnormalities were abolished with indomethacin which was responsible for a marked decrease in urinary. The data and the family study suggest that this condition is a proximal tubular disorder with atuosomal recessive inheritance.