Prophylactic use of antibiotics
Jackson, G.G.
Münchener Medizinische Wochenschrift 121(36): 1137-1139
1979
ISSN/ISBN: 0341-3098 PMID: 114783 Document Number: 140022
The correlation between extensive aminoglycoside usage and the resistance of P. aeruginosa and Enterobacteriaceae (up to 40%) is a particularly striking aspect in hospitals. Favourable conditions for an effective prophylaxis are the limitation to one pathogen, a defined location and recent contamination. In so-called "clean" operations, prophylaxis is reasonably justified in exceptional cases only. Likewise, no benefit is to be expected from chemoprophylaxis in most of the so-called "clean-contaminated" surgical procedures. In septic surgery, antibiotic prophylaxis is indicated even if effectiveness is limited. Indiscriminate routine use, longterm treatment and local application of antibiotics to intensely contaminated areas is definitely not to be recommended.