Hematopoietic and lymphoid cell adhesion to stromal mechanocytes in vitro
Luriia, E.A.; Kuznetsov, S.A.; Genkina, E.N.
Biulleten' Eksperimental'noi Biologii i Meditsiny 88(12): 703-704
1979
ISSN/ISBN: 0365-9615 PMID: 519003 Document Number: 139215
In vitro adhesion of guinea pig bone marrow and spleen cells to cultured fibroblasts of bone marrow, spleen, thymus and peritoneal fluid origin was studied. Much better binding of myeloid cells to fibroblasts than to macrophages was observed, but no difference in adhesion to stromal fibroblasts of different origin was focund. The number of adhereing cells per one stromal mechanocyte depends on the number of adhesion sites on the surface of target cells. According to our data, adhesion sites for myeloid cells are much more numerous, than adhesion sites for lymphoid cells.