New hydrophilic vehicle enabling rectal and vaginal absorption of insulin, heparin, phenol red and gentamicin
Touitou, E.; Donbrow, M.; Azaz, E.
Journal of Pharmacy and Pharmacology 30(10): 662-663
1978
ISSN/ISBN: 0022-3573 PMID: 30828 Document Number: 138096
A hydrophilic vehicle from which systemic action is obtained after rectal or vaginal administration of drugs not normally active via the gastrointestinal tract was developed. The base comprised the non-ionic surface-active agent Cetomacrogol 1000 (polyethylene glycol 1000 monocetyl ether) in combination with various concentrations of polyethylene glycols. Concentrations of the components and molecular weights of the polyethylene glycols varied according to the consistency required to obtain dosage forms ranging from solid suppositories to semi-solid micro-enemas or vaginal applications. The cetomacrogol base was tested in vivo in rats. The cetomacrogol base is evidently effective in introducing the drugs systemically by the rectal or vaginal route. Its use may possibly open a way to the development of alternative routes of administration of drugs hitherto given parenterally and causing patient compliance or other problems.