Multiple systemic and periocular malformations associated with the fetal hydantoin syndrome
Wallar, P.H.; Genstler, D.E.; George, C.C.
Annals of Ophthalmology 10(11): 1568-1572
1978
ISSN/ISBN: 0003-4886 PMID: 103474 Document Number: 136985
Anticonvulsants remain necessary during pregnancy and the removal of such drugs is not recommended. However, on the available evidence, the physician may expect an increased risk of malformation including eye abnormalities as has been outlined. The abnormalities include growth deficiencies and delayed motor/mental development together with dysmorphic features, the most common of which seems to be cleft lip/cleft palate. Additionally, many of these children suffer from eye abnormalities including hypertelorism, ptosis, strabismus, epicanthal folds, and in this case abnormalities of the lacrimal apparatus.