Effect of indomethacin on aldosterone secretion in chronic sodium depletion
Spät, A.; Fejes Tóth, G.
Acta Physiologica Academiae Scientiarum Hungaricae 52(1): 87-91
1978
ISSN/ISBN: 0001-6756 PMID: 754490 Document Number: 136646
Aldosterone secretion rate was determined in sodium repleted and sodium depleted rats 3 to 5 hours hypophysectomy. Sodium depletion was performed by keeping the rats on wheat for six days. This diet resulted in a significant increase in aldosterone secretion rate. Hypersecretion of aldosterone could be observed also after administration of indomethacin, an inhibitor of prostaglandin synthesis.
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