Mitomycin C in the treatment of keloids: a case and review
Kleinerman, R.; Kilmer, S.L.; Chotzen, V.A.
Journal of Drugs in Dermatology Jdd 12(6): 701-703
2013
ISSN/ISBN: 1545-9616 PMID: 23839191 Document Number: 13583
Mitomycin C (MMC) is an antineoplastic antibiotic that has been used off-label in the treatment of hypertrophic scars and keloids. Herein we report our successful use of this agent in a patient with sternal keloids refractory to other means of therapy. We further review the literature regarding the use of MMC in the treatment of keloids.
Document emailed within 1 workday
Related Documents
Shockman, S.; Paghdal, K.V.; Cohen, G. 2010: Medical and surgical management of keloids: a review Journal of Drugs in Dermatology: Jdd 9(10): 1249-1257Kischer, C.W. 1992: The microvessels in hypertrophic scars, keloids and related lesions: a review Journal of Submicroscopic Cytology and Pathology 24(2): 281-296
Punga-Maole, M.L.; Hubert, J.; Mangin, P. 1995: Bladder retraction, a complication of chemoprophylaxis of superficial bladder cancer using intravesical mitomycin C. Apropos of a case and review of the literature Progres en Urologie: Journal de l'Association Francaise d'Urologie et de la Societe Francaise d'Urologie 5(4): 580-585
Chen, Y.; Dong, F.; Wang, X.; Xue, J.; Zhang, H.; Gao, L.; Zhang, Q.; Chen, X. 2014: Postoperative carbon ion radiotherapy for keloids: a preliminary report of 16 cases and review of the literature Wounds: a compendium of clinical research and practice 26(9): 264-272
Rusciani, L.; Paradisi, A.; Alfano, C.; Chiummariello, S.; Rusciani, A. 2006: Cryotherapy in the treatment of keloids Journal of Drugs in Dermatology: Jdd 5(7): 591-595
Viera, M.H.; Caperton, C.V.; Berman, B. 2011: Advances in the treatment of keloids Journal of Drugs in Dermatology: Jdd 10(5): 468-480
Ceović, R.; Lipozenčić, J.; Bukvić Mokos, Z.; Stulhofer Buzina, D.šk.; Kostović, K.ši. 2010: Why don't we have more effective treatment for keloids? Acta Dermatovenerologica Croatica: Adc 18(3): 195-200
Kik, A.; Bachurzewski, J. 1975: Treatment of keloids with grenz rays Przeglad Dermatologiczny 62(4): 559-564
Edsmyr, F.; Larson, L.G.; Onyango, J.; Wanguru, S.; Wood, M. 1973: Radiotherapy in the treatment of keloids in East Africa East African Medical Journal 50(8): 457-461
Zouboulis, C.C.; Orfanos, C.E. 1990: Cryosurgical treatment of hypertrophic scars and keloids Der Hautarzt; Zeitschrift für Dermatologie Venerologie und verwandte Gebiete 41(12): 683-688
Jaworski, S. 1972: Use of corticoids in local treatment of hypertrophic scars and keloids in children Polski Przeglad Chirurgiczny 44(12): 1823-1827
Chuangsuwanich, A.; Osathalert, V.; Muangsombut, S. 2000: Self-adhesive silicone gel sheet: a treatment for hypertrophic scars and keloids Journal of the Medical Association of Thailand 83(4): 439-444
Gupta, V.P.; Saxena, T. 2003: Comparison of single-drop mitomycin C regime with other mitomycin C regimes in pterygium surgery Indian Journal of Ophthalmology 51(1): 59-65
Hashida, M.; Kato, A.; Takakura, Y.; Sezaki, H. 1984: Disposition and pharmacokinetics of a polymeric prodrug of mitomycin C, mitomycin C-dextran conjugate, in the rat Drug Metabolism and Disposition: the Biological Fate of Chemicals 12(4): 492-499
Siegel, D.; Gibson, N.W.; Preusch, P.C.; Ross, D. 1990: Metabolism of mitomycin C by DT-diaphorase: role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells Cancer Research 50(23): 7483-7489
Berman, B.; Patel, J.K.; Perez, O.A.; Viera, M.H.; Amini, S.; Block, S.; Zell, D.; Tadicherla, S.; Villa, A.; Ramirez, C.; De Araujo, T. 2008: Evaluating the tolerability and efficacy of etanercept compared to triamcinolone acetonide for the intralesional treatment of keloids Journal of Drugs in Dermatology: Jdd 7(8): 757-761
Converse, J.M.; Stallings, J.O. 1972: Eradication of large auricular keloids by excision, skin grafting, and intradermal injection of triamcinolone acetonide solution. Case report Plastic and Reconstructive Surgery 49(4): 461-463
Sulkes, A.; Uziely, B.; Isacson, R.; Brufman, G.; Biran, S. 1988: Combination chemotherapy in metastatic tumors of unknown origin. 5-Fluorouracil, adriamycin and mitomycin C for adenocarcinomas and adriamycin, vinblastine and mitomycin C for anaplastic carcinomas Israel Journal of Medical Sciences 24(9-10): 604-610
Werenne, X.; Hermesse, J.; Coucke, P.; Louviaux, I.; Goffin, F. 2013: Clinical case of the month. The role of radiotherapy for the treatment of advanced squamous cell carcinoma of the vulva. Case report and review of the literature Revue Medicale de Liege 68(7-8): 391-395
de Monès, E.; Lagarde, F.; Hans, S.; Ménard, M.; Laccourreye, O.; Brasnu, D. 2004: Mitomycin C: prevention and treatment of anterior glottic synechia Annales d'Oto-Laryngologie et de Chirurgie Cervico Faciale: Bulletin de la Societe d'Oto-Laryngologie des Hopitaux de Paris 121(4): 229-234