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Importance of cooling after death for restoration of metabolism during resuscitation

Pogosova, A.V.; Petukhova, L.M.; Nikulin, V.I.; Konikova, A.S.

Voprosy Meditsinskoi Khimii 24(6): 811-816

1978

ISSN/ISBN: 0042-8809
PMID: 734984
Document Number: 134817
Incorporation of labelled metabolites into proteins, RNA and DNA was completely inhibited in rabbit tissues under conditions of prolonged hypothermia (10 degrees). The incorporation of labelled metabolites into all the biopolymers studied was restored after subsequent warming up to 38 degrees. Within 60-90 min after death of the animals due to acute anoxia, the labelled metabolites did not incorporate into protein, RNA and DNA. Artificial postmortal hypothermia (20 degrees) increased (by about 2.5-3-fold) the period of viability, during which reanimation is possible. The hypothermia enables subsequent restoration of the anabolic processes from the zero level.

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