Management of Parkinson's disease in 2009
Maertens de Noordhout, A.
Revue Medicale Suisse 5(214): 1650-1655
2009
ISSN/ISBN: 1660-9379 PMID: 19772196 Document Number: 13449
The cause of Parkinson's disease remains unknown and no cure or prevention exists so far. Levodopa remains by far the most potent symptomatic therapy, but induces side-effects such as motor fluctuations and abnormal movements, which can somewhat be counterbalanced by optimizing levodopa plasma levels or acting at receptors level with long half-life dopamine agonists. In severe cases, functional surgery with deep brain stimulation can be offered. Some non-dopaminergic symptoms like dementia, freezing, postural instability or dysautonomia do not respond to dopaminergic drugs and need special care.
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