Norepinephrine turnover under neuroleptic treatment of schizophrenic syndromes
Eben, E.; Ackenheil, M.; Rüther, E.
Arzneimittel-Forschung 28(9): 1498
1978
ISSN/ISBN: 0004-4172 PMID: 38809 Document Number: 134232
In 45 psychotic in-patients with the paranoid-hallucinatory syndrome, the psychopathology, the extrapyramidal motor disturbances and 3-methoxy-4-hydroxy-phenylethyleneglycol (MHPG) in CSF were investigated. A 15-day treatment with haloperidol induced significant increase of MHPG in CSF; after 10 days clozapine treatment MHPG was significantly reduced. 10 days later the normal values were reached again. The investigation of MHPG in CSF under treatment with neuroleptics showed no correlation between antipsychotic activity and the turnover of central norepinephrine.