Fluid space in bone
Hughes, S.; Davies, R.; Khan, R.; Kelly, P.
Clinical Orthopaedics and Related Research 134: 332-341
1978
ISSN/ISBN: 0009-921X PMID: 729259 Document Number: 134118
This paper reviews the extraction of solutes through capillaries in bone, by means of outflow dilution techniques in the canine tibia. Solutes leave capillaries in bone by passive diffusion dependent on molecular size. The fluid space in bone is also examined by means of analyzing washout curves of radioactive substances. It is proposed that there are 4 definable compartments in bone; a vascular space, a perivascular fluid space a bone fluid space and a bone space. The relevance of these spaces is in bone mineral short and long term ion exchange activity.