Low cost combination of DCIP and MCV was better than that of DCIP and OF in the screening for hemoglobin e
Prayongratana, K.; Polprasert, C.; Raungrongmorakot, K.; Tatone, K.; Santiwatanakul, S.
Journal of the Medical Association of Thailand 91(10): 1499-1504
2008
ISSN/ISBN: 0125-2208 PMID: 18972891 Document Number: 13406
To evaluate hemoglobin E screening tests in a large scale of cases. A cross-sectional descriptive study was conducted Whole blood obtained from subjects was evaluated for CBC, OF, DCIP, and hemoglobin typing. Five hundred twenty seven hemoglobin E and 280 reference subjects participated. DCIP's sensitivity, specificity, positive predictive value, and negative predictive value were 97.16%, 98.93%, 99.42%, and 95.19%, respectively. These values of OF were 69.12%, 80.00%, 86.67%, and 57.88%, respectively. In the combination of DCIP and OF gave rise to these values of 99.43%, 79.29%, 90.03%, and 96.67%, respectively. Finally the combination of DCIP and MCV < 80 fL resulted in these values to be 99.43%, 98.93%, 99.43%, and 98.93%, respectively. False positive and false negative rate were 1.07% and 0.57%, respectively. Combination of DCIP and MCVwas better than that of DCIP and OF in hemoglobin E screening.
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