Multivariate investigation of reactions to tranquilizers dependent on personality variables
Boucsein, W.; Werner, J.
Arzneimittel-Forschung 28(8): 1306-1308
1978
ISSN/ISBN: 0004-4172 PMID: 380580 Document Number: 133875
5 mg of diazepam as well as 2.5, 5, and 10 mg of a substance from the thienodiazepine series (Bay g 5653) were compared with a placebo, following a double-blind procedure. The 149 male student volunteers were classified into introverts and extraverts. For 17 test variables including subjective and physiological measures, as well as psychomotoric and cognitive achievement variables, a 2 x 5-factorial MANOVA was computed. Effects of medication and of interactions between introversion/extraversion and medication were highly significant. Correlations of test variables with composite scores indicated that medication effects could be shown best with objective tests, while the interactions between introversion/extraversion and medication could be shown better with subjective variables. Results were discussed together with those of an earlier univariate analysis of the data using emotional stability/lability as a personality variable.