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Steric influence on inhibition of monoamine oxidase forms by 2,3-dichloro-alpha-methylbenzylamine

Fuller, R.W.; Hemrick, S.K.

Research Communications in Chemical Pathology and Pharmacology 20(1): 199-202

1978

ISSN/ISBN: 0034-5164
PMID: 663404
Document Number: 133252
The (+) isomer of 2,3-dichloro-alpha-methylbenzylamine inhibited the oxidation of serotonin (a substrate of type A MAO) by rat brain mitochondrial monoamine oxidase (MAO) more effectively than it inhibited the oxidation of phenylethylamine (a substrate for type B MAO). In contrast, the (-) isomer inhibited phenylethylamine oxidation more than it inhibited serotonin oxidation. These apparently are the first pair of stereoisomers observed to have opposite selectivity as inhibitors of types A and B MAO.

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