Fluorescent analogue of ampicillin
Kusnír, J.; Adameová, V.; Barna, K.
Arzneimittel-Forschung 28(11): 2058-2061
1978
ISSN/ISBN: 0004-4172 PMID: 582906 Document Number: 133171
As the outcome of the reaction of ampicillin with 4-phenylspiro[furan-2(3H),1'-phthalane]-3,3'-dione (fluorescamine), the chemical analogue of ampicillin (F-AMPI) has been prepared. This preparation has manifested strong fluorescence in UV light. Some basic chemical and biological properties of this product such as chemical stability electrophoretic mobility, uniformity during thin-layer chromatography and ion-exchange chromatography, and antimicrobial activity were examined. The results were compared with values of the original antibiotic.