Incremental intravenous nitroglycerin for control of afterload during anesthesia in patients undergoing myocardial revascularization
Stengert, K.B.; Wilsey, B.L.; Hurley, E.J.; Grehl, T.M.; Lurie, A.J.; Klein, R.C.; Upjohn, L.R.
Der Anaesthesist 27(5): 223-227
1978
ISSN/ISBN: 0003-2417 PMID: 96704 Document Number: 132767
In 25 patients undergoing coronary artery bypass grafting hemodynamic measurements (including values obtained with Swan-Ganz catheterization in 21 of the patients) were made before and after administering a bolus injection of 64 or 96 mcg of nitroglycerin to relieve intraoperative hypertension. This pharmacological agent reduced afterload and preload without raising heart rate. The effect was apparent within 1-3 min and lasted 5-10 min. Untoward hypotension was not encountered in any instance. This intervention appears to be a safe approach to the treatment of intraoperative hypertension in patients with coronary artery disease.