Disseminated intravascular coagulation in acute promyelocytic leukemia. Possibility of treatment with glucocorticoids at high doses
Leone, G.; Mango, G.; Alfano, G.
Nouvelle Revue Francaise d'Hematologie 20(3): 395-401
1978
ISSN/ISBN: 0029-4810 PMID: 289100 Document Number: 132752
Seven patients affected by acute promyelocytic leukemia and presenting a hemorrhagic syndrome with hypofibrinogenemia have been treated with Daunorubicin and high doses of Glucocorticoids. In three out of the seven patients we also added an antiprotease agent (Trasylol, Bayer). Hemorrhagic diathesis has been controlled in all patients but one without massive platelet transfusions. A complete hematologic remission with prolonged survival was achieved in five patients.