Herpes simplex virus latency in patients with multiple sclerosis, lymphoma and normal humans
Warren, K.G.; Devlin, M.; Gilden, D.H.; Wroblewska, Z.; Koprowski, H.; Brown, S.M.; Subak-Sharpe, J.
Iarc Scientific Publications 1978(24 Part 2): 765-768
1978
ISSN/ISBN: 0300-5038 PMID: 221401 Document Number: 132084
Herpes simplex virus (HSV) was isolated from the trigeminal ganglia (TG) of 12 cadavers (10 traumatic deaths, one lymphoma and one multiple sclerosis). The cadaver with multiple sclerosis showed large bilateral trigeminal nerve root entry zone areas of demyelination. It is hypothesized that HSV is capable of migrating to the trigeminal nerve root entry zone and initiating demyelinating disease.
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