Membranous glomerulonephritis associated with anti-tubular and anti-alveolar basement membrane antibodies
Levy, M.; Gagnadoux, M.F.; Beziau, A.; Habib, R.
Clinical Nephrology 10(4): 158-165
1978
ISSN/ISBN: 0301-0430 PMID: 363319 Document Number: 131768
The renal biopsy of a 3-year old boy with complete Fanconi syndrome showed the association of a membranous glomerulonephritis with severe tubulointerstial changes. Immunofluorescence microscopy disclosed linear and granular deposits of Ig along tubular basement membranes. The presence of anti-tubular basement membrane antibodies in the patient's serum was demonstrated by indirect immunofluorescence and radioimmunoassay. The child also developed pulmonary involvement associated with episodes of acute anemia. Anti-alveolar basement membrane antibodies were detected by indirect immunofluorescence. The present case is the first reported example of auto-immune disease characterized by the presence of anti-tubular and alveolar basement membrane antibodies associated with an immune complex glomerulonephritis.