Inotropic agents for treatment of acute heart failure syndromes in intensive care

Rusca, M.; Liaudet, L.

Revue Medicale Suisse 5(229): 2512-2515

2009


ISSN/ISBN: 1660-9379
PMID: 20084871
Document Number: 13164
Acute Heart Failure Syndromes are defined as the rapid progression, or de novo presentation, of heart failure signs and symptoms. When clinical signs of low cardiac output are present, therapy with positive inotropic agents in an acute cardiac care unit is mandatory. Three classes of inotropic drugs are currently available, including beta-adrenergic agonists (especially dobutamine), phosphodiesterase inhibitors (such as milrinone) and the recently developed calcium sensitizers (levosimendan). In this article, we summarize the mechanisms of action of these different classes of drugs, and also discuss important issues regarding their clinical indications and the potential risks associated with their use.

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Inotropic agents for treatment of acute heart failure syndromes in intensive care