Primary and secondary abnormalities of T cell subpopulations
Trompeter, R.S.; Layward, L.; Hayward, A.R.
Clinical and Experimental Immunology 34(3): 388-392
1978
ISSN/ISBN: 0009-9104 PMID: 311259 Document Number: 131375
Ataxia telangiectasia patients had normal numbers of T M-binding T lymphocytes (TM) were selectively reduced. These changes provide a cellular basis for the defects in cell-mediated immunity which occur in this primary condition. One child with severe combined immunodeficiency lacked TM and IgG-binding (TG) T lymphocytes, but no consistent abnormalities of T cell subsets were found in other primary immunodeficiency syndromes. Secondary increases in IgG-binding T lymphocytes (TG) were found in children receiving steroids.