Immunological reactivity and the prognosis for allergic complications in the crew of the 2d Saliut-4 expedition
Konstantinova, I.V.; Nefedov-Yu, G.; Eremin, A.V.; Drozdova, V.I.; Skryabin, A.S.; Guseva, O.A.; Mukhina, N.N.
Kosmicheskaia Biologiia i Aviakosmicheskaia Meditsina 12(2): 15-19
1978
ISSN/ISBN: 0321-5040 PMID: 305975 Document Number: 131150
Immunological reactivity of P. I. Klimuk and V. I. Sevastyanov was studied before and after their 63-day flight aboard the orbital station Salyut-4. The study used the methods to assay reactivity of T- and B-lymphocytes (PHA-blast-transformation, nonspecific formation of rosettes with sheep red blood cells, immunofluorescence to identify cells carrying immunoglobulin receptors on their surface, serum level of immunoglobulins as a function of Becells). Sensitization of the human body to allergenes of representatives of normal automicroflora of Staphylococcus, Streptococcus, Proteus and E. coli was examined. Specific immunological reactivity which was marked on the 2nd day and tended to return to normal on the 7th day postflight as well as a significant decrease of IgA were noted. Postflight P. I. Klimuk showed sensitization to allergens of Staphylococcus and Streptococcus. Results of immunological examinations of the first and second expeditions aboard the orbital station Salyut-4 were compared.