A multicentre evaluation of sustained release oxprenolol in the management of hypertension in hospital out-patient practice
Forrest, W.A.
Journal of International Medical Research 6(2): 136-140
1978
ISSN/ISBN: 0300-0605 PMID: 631415 Document Number: 131012
Patients (102) with essential hypertension, managed in hospital out-patient clinics in the United Kingdom on a drug regime of .beta.-receptor antagonist alone, or in combination with a diuretic were successfully transferred to once daily sustained release oxprenolol. Where a diuretic was prescribed the dose remained unchanged. Improved control of blood pressure was recorded in the majority of patients with 1 or 2 morning tablets of sustained release oxprenolol. Preference for once daily therapy, enthusiasm for the calendar pack and a net increase in the mean daily dosage of a .beta.-receptor antagonist were the probable factors contributing to the improvement recorded. Once daily sustained release oxprenolol would appear, in most hypertensive patients, to be an effective substitute for multi-dose treatment with .beta.-receptor antagonists in conventional formulation.