Adjuvant treatment of osteogenic sarcoma with high-dose cyclophosphamide
Shepp, M.; Necheles, T.F.; Banks, H.H.; Oh, W.H.; Zimbler, S.
Cancer Treatment Reports 62(2): 295-296
1978
ISSN/ISBN: 0361-5960 PMID: 346220 Document Number: 131010
Six patients with osteosarcoma and no evidence of metastases received postoperative adjuvant chemotherapy with high-dose cyclophosphamide (25 mg/kg iv every other day for five doses). Three of these patients are alive without evidence of disease at 2 1/2, 3, and 5 years following diagnosis. The regimen was tolerable in terms of toxicity. Cyclophosphamide in high doses may be effective adjuvant therapy in some patients with osteosarcoma.
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