Hemodynamics in patients with coronary heart disease under conditions of physical exercise before and after mepindolol-sulfate
Bonelli, J.; Magometschnigg, D.; Hitzenberger, G.; Kaik, G.
Zeitschrift für Kardiologie 67(1): 51-56
1978
ISSN/ISBN: 0300-5860 PMID: 343412 Document Number: 130515
The effect of exercise upon hemodynamic variables was investigated in seven patients with coronary artery disease during an eight-week double blind cross-over study with placebo and with mepindolol-sulfate, a new beta-receptor blocking agent. 1. The first hemodynamic sign of myocardial ischemia during exercise was an increase of pulmonary capillary pressure in parallel with ST-segment depression in the Ecg. 2. Angina was accompanied by a fall of the stroke volume and an increase of the peripheral resistance. 3. During beta-receptor blockade with mepindolol-sulfate angina was compensated, the unfavourable hemodynamic effects seen during placebo did not occur. 4. No signs of congestive heart failure were found during mepindolol-sulfate-therapy. 5. Mepindolol-sulfate showed a pronounced blood-pressure lowering effect.