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Dependence of the lethal and mutagenic effect of mitomycin C and UV rays on the Streptoverticillium mucoheptinicum spore germination process

Zhukova, R.A.; Nabokova, L.P.; Starshinova, E.N.; Tereshin, I.M.

Antibiotiki 23(2): 149-153

1978

ISSN/ISBN: 0003-5637
PMID: 629527
Document Number: 130217
The lethal and mutagenic effects of the DNA-tropic antibiotic mithomycin C and UV-light on Streptoverticillium mycoheptinicum during the period of the spore replication were studied. The spores were more stable to the effect of the mutagens during DNA replication after 120 minutes of incubation. The mutagenic activity of mithomycin C and UV-light was closely connected with the quantitative changes in the genetic material of the pores. During DNA replication the rate of the morphological mutants was the highest. With respect to production of mycoheptin the spores were most mutable under the effect of mithomycin C during the period of DNA replication, while under the effect of UV-light they were most mutable at the lag-phase.

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