Growth hormone: the effect on skeletal renewal in the adult dog. I. Morphometric studies
Harris, W.H.; Heaney, R.P.; Jowsey, J.; Cockin, J.; Akins, C.; Graham, J.; Weinberg, E.H.
Calcified Tissue Research 10(1): 1-13
1972
ISSN/ISBN: 0008-0594 PMID: 4626613 Document Number: 13
In intact adult dogs of both sexes exogenous growth hormone induced a marked increase in new bone formation. The net effect on resorption could not be defined quantitatively but endosteM resorption was decreased. Intracortical resorption was increased but intraeortical porosity rose only slightly. In addition to the decrease in endosteal resorption, there was abundant endosteal new bone formation. This rise in endosteal new bone formation plus the marked stimulus to periosteal new bone formation led to a net increase in skeletal mass. The bone formed was normal histologically and microradiographieally, Despite a marked rise in new bone formation, alkaline phosphatase values remained unchanged.
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