The mechanism of circulatory hypoxia in acute with sodium fluoride poisoning
Sumina, E.N.; Shugaev, V.A.; Shugaev, V.A.
Farmakologiia i Toksikologiia 41(4): 480-482
1978
ISSN/ISBN: 0014-8318 PMID: 668876 Document Number: 128736
Intraperitoneal injection of a 1-sodium fluoride solution (35--40 mg/kg) to male rats was seen to cause a 8--9 fold rise of the blood histamine content and to significantly lower the oxygen tension in the musculus femorins. Preliminary administration of diprazine (5 mg/kg) prevented the death of the animals and lowered the degree of oxygen deficiency in the tissues. An interference is drawn on the important pathophysiological role played by an increase of the histamine content in the blood of the animals in the mechanism underlying the development of circulatory hypoxia in acute poisoning with sodium fluoride.