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Effects of oxyfedrine on left ventricular function in patients several months after myocardial infarction

Ressl, J.; Kasalický, J.

International Journal of Clinical Pharmacology and Biopharmacy 16(10): 474-478

1978

ISSN/ISBN: 0340-0026
PMID: 359492
Document Number: 128470
Left ventricular (LV) function was investigated by left heart catheterization at rest and during exercise in 15 men 3--5 months after acute myocardial infarction. The effect of 8 mg oxyfedrine i.v. in 10 patients was compared to placebo in 5. The administration of oxyfedrine led to a significant decrease of LV end-diastolic pressure; an increase of LV dp/dt max, heart rate, LV ejection fraction and LV stroke work; and a shift of LV function curve indicating its improvement. These results give evidence for a positive inotropic effect of this drug which could have therapeutic implications in patients with impaired LV function after myocardial infarction.

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