Hba 1c as a Tool for the Diagnosis of Type 2 Diabetes: Comparison with Fasting Glucose
Tatsch, E.; Bochi, G.V.; Sílvia Piva, J.; Pereira, R.S.; Kober, H.; José Antonio M. Carvalho, D.; Sangoi, M.B.; Marta Duarte, M.M.F.; Moresco, R.N.
Clinical Laboratory 58(3-4): 347-350
2012
ISSN/ISBN: 1433-6510 PMID: 22582512 Document Number: 12835
Background: Glycated hemoglobin (HbA 1c ) has been proposed for the diagnosis of diabetes. However, several countries have not incorporated its use for this purpose yet and there is no consensus on a suitable cut-off point of HbA 1c for the diagnosis of diabetes. Thus, the aim of this study was to evaluate the diagnostic characteristics of HbA 1c and fasting plasma glucose (FPG) for the assessment of type 2 diabetes. Methods: FPG, HbA 1c , and creatinine levels were assessed in 47 patients with type 2 diabetes and 46 healthy controls. Results: The areas under the curve for HbA 1c ≥6.5% and FPG ≥7.0 mmol/L were 0.97 and 0.92, respectively. HbA 1c has a slightly higher ability to discriminate type 2 diabetes compared with FPG. The association between HbA 1c and type 2 diabetes was independent of gender, age, hypertension, smoking, and body mass index. Conclusions: HbA 1c was able to be used for the diagnosis of type 2 diabetes.
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