Granulocyte-colony stimulating factors for secondary prevention of leucopenia in patients receiving chemotherapy
Lowathanasirikul, J.; Manusirivithaya, S.; Tangjitgamol, S.; Leelahakorn, S.
Journal of the Medical Association of Thailand 89 Suppl. 4: S47-S53
2006
ISSN/ISBN: 0125-2208 PMID: 17726809 Document Number: 12793
To evaluate the effectiveness of GCSF as a secondary preventive adjunct to chemotherapy in the gynaecologic cancer patients who previously had grade 3-4 neutropenia or leucopenia from chemotherapy. We retrospectively reviewed the medical records of 94 chemotherapeutic cycles with GCSF as secondary prophylaxis in 29 patients with gynaecologic malignancy between January 1996 and April 2005. The median age of the patients was 51 years (21-75). Most of the patients had ovarian cancers (19 cases, 65.6%). From secondary GCSF, grade 4 neutropenia was developed in 12 of 94 cycles (12.8%), and grade 4 leucopenia was developed in 5 of 94 cycles (5.3%). There were no patients developing febrile neutropenia after GCSF support. Secondary GCSF prophylaxis was effective in preventing grade 4 leucopenia, grade 4 neutropenia, and febrile neutropenia.