Generalized necrobiotic xanthogranuloma successfully treated with lenalidomide
Silapunt, S.; Chon, S.Y.
Journal of Drugs in Dermatology Jdd 9(3): 273-276
2010
ISSN/ISBN: 1545-9616 PMID: 20232591 Document Number: 12766
Necrobiotic xanthogranuloma (NXG) presents a therapeutic challenge to clinicians. Generalized NXG has limited treatment options. A patient presented to the authors with generalized NXG associated with monoclonal gammopathy of unknown significance (MGUS), a plasma cell dyscrasia considered to be a precursor to multiple myeloma. The patient was treated with lenalidomide, a derivative of thalidomide with efficacy in treatment of multiple myeloma. Resolution of paraproteinemia was associated with resolution of NXG.
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