Modulatory effect of the sympathetic nervous system on neuroblastoma tumor growth
Chelmicka-Schorr, E.; Arnason, B.G.
Cancer Research 38(5): 1374-1375
1978
ISSN/ISBN: 0008-5472 PMID: 639065 Document Number: 127122
Growth of C-1300 neuroblastoma was markedly suppressed in mice chemically sympathectomized at birth with 6-hydroxydopamine. Growth of A-10 adenocarcinoma was also somewhat reduced. In newborn mice pretreated with nerve growth factor to induce sympathetic nervous system neuronal hypertrophy, neuronal maturation, and peripheral hyperinnervation, the growth of neuroblastoma was augmented.
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