Influence of inhibition of angiotensin I converting enzyme with SQ-14225 on the arterial blood pressure of mongrel dogs
Jandhyala, B.S.; Washington, G.F.; Lokhandwala, M.F.
Research Communications in Chemical Pathology and Pharmacology 22(2): 257-265
1978
ISSN/ISBN: 0034-5164 PMID: 216064 Document Number: 126871
Effects of SQ-14225 [D-3-mercapto-2-methylpropanoyl-L-proline; 0.1, 0.3, and 3.0 mg/kg, i.v.] on the pressor responses to angiotensin I (A-I) and on the arterial blood pressure were investigated in anesthetized mongrel dogs. All 3 doses significantly inhibited A-I induced pressor response (70-80%); however, reduction in the blood pressure was noted only with the highest dose used. Neither bilateral nephrectomy, autonomic ganglionic blockade nor pretreatment with saralasin, an angiotensin II antagonist, altered the hypotensive activity of SQ-14225 (3 mg/kg, i.v.). Significant inhibition of angiotensin converting enzyme apparently does not result in a decrease in the blood pressure in dogs; the hypotension produced by SQ-14225 may involve a mechanism yet to be identified.