Protection against MOPC-315 plasmacytoma by immunization with C-type particle preparations
Kleinman, R.; Dray, S.
Cancer Research 38(1): 223-225
1978
ISSN/ISBN: 0008-5472 PMID: 201375 Document Number: 126833
Mice were given injections of C-type particles extracted from the ascitic fluid of plasmacytoma-bearing mice. These particles, extracted from MOPC-315 tumor-bearing mice and injected into BALB/c mice, protected them against challenge with MOPC-315 tumor cells. The protection was dependent upon tumor cell dose; 66% survival was observed with a lethal dose of tumor cells. No protection was observed against challenge with another plasmacytoma (S13). Attempts to protect mice against S-13 plasmacytoma by immunizing them with C-type particles originating from S-13 tumor-bearing mice were unsuccessful.