Preventive effect of inhibitors of catecholamine synthesis, serotonin and adrenoblockaders on anovulatory syndrome development in neonatally androgenized rats. 2
Nosenko, N.D.; Reznikov, A.G.
Problemy Endokrinologii 24(6): 69-73
1978
ISSN/ISBN: 0375-9660 PMID: 152916 Document Number: 126535
Administration to female rats of 250 micrograms of testosterone propionate (TSP) on the 3rd day of postnatal life led to reduction of estradiol, progesterone, and, to a lesser degree, of lutropin in the blood plasma of these animals at the age of 3 months. There was an increase of the lutropin content in the adenohypophysis and of luliberin in the hypothalamus. Combined with TSP administration of alpha-methyl-p-tyrosine, p-chlorphenylalanine or droperidol promoted preservation of cyclic changes in the hypothalamic gonadotropin activity and partially prevented disturbances of estradiol and progesteron secretion caused by neonatal androgenization. The mechanisms of participation of biogenic monoamines in sex differentiation of the hypothalamus are discussed.