Studies on possible interactions of thalidomide and genetic material from chicken embryos
Sonnenbichler, J.; Lüling, L.
Arzneimittel-Forschung 28(9): 1567-1570
1978
ISSN/ISBN: 0004-4172 PMID: 582557 Document Number: 125444
Tritium labelled thalidomide was applied to chicken embryos of various stages and the distribution of the readioactive label was investigated. No specific binding tendency to components of the cell could be found, especially no affinity to nucleic acids and to the chromosomal proteins (histones and non-histones) could be observed, which had been discussed hypothetically. An influence on DNA replication and transcription rate could also not be detected.