Evaluation of Renal Damage by Urinary Beta-Trace Protein in Patients with Chronic Kidney Disease

Dajak, M.; Ignjatovi, S.ć; Stojimirovi, B.ć; Snežana Gajić; Majki, N.ć-Singh

Clinical Laboratory 57(1-2): 29-36

2011


ISSN/ISBN: 1433-6510
PMID: 21391462
Document Number: 12526
Background: Beta-trace protein (BTP) was found to be increased in the serum and urine of patients with renal diseases. The aim of this study was to compare the urinary levels of beta-trace protein with levels of other urinary proteins: albumin, β2-microglobulin (B2M), α1-microglobulin (A1M), and cystatin C and to determine its clinical usefulness for detection of renal dysfunction in chronic kidney disease (CKD). Methods: These markers were measured in 24-hour urine samples from 134 patients with CKD. Results: BTP correlated significantly with A1M (r = 0.871), cystatin C (r = 0.759), total protein (r = 0.684), B2M (r = 0.497), and albumin (r = 0.448) in 24-hour urine samples (P 30 mg / day albuminuria (AUC 0.908). Urinary BTP was also in significant correlation with the estimated glomerular filtration rate (r = -0.580). Conclusions: The results of our study suggest that BTP may be a useful and reliable urinary marker of renal dysfunction and may have a place in addition to urinary α1-microglobulin and albumin as an alternative marker for tubular damage and the magnitude of renal impairment in patients with chronic kidney disease.

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Evaluation of Renal Damage by Urinary Beta-Trace Protein in Patients with Chronic Kidney Disease