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Degradation of tropoelastin by proteases

Christner, P.; Weinbaum, G.; Sloan, B.; Rosenbloom, J.

Analytical Biochemistry 88(2): 682-688

1978

ISSN/ISBN: 0003-2697
PMID: 29521
Document Number: 125175
A simple assay is described which is capable of detecting single breaks in purified radioactively labeled tropoelastin after incubation with dilute solutions of proteases. Using this assay it is shown that tropoelastin is rapidly cleaved by a variety of proteases, including leukocyte and pancreatic elastase, at physiologic pH and ionic strength. The results suggest the possibility that degradation of tropoelastin or other related biosynthetic intermediates may play a role in the pathogenesis of emphysema.

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