Degenerative retinal conditions after treatment with Busulfan during pregnancy
Saraux, H.; Lefrancois, A.
Klinische Monatsblatter für Augenheilkunde 170(6): 818-820
1977
ISSN/ISBN: 0023-2165 PMID: 268448 Document Number: 123825
A patient with chronic granulocytic leukemia was treated with Busulfan for the three last months of pregnancy. The infant appeared normal except for an atypical tapetoretinal degeneration. We studied the other cases in the literature. All pregnancies produced an apparently normal infant although three infants were small. The case of Diamond had microphthalmia. We conclude that Busulfan is perhaps toxic to fetal retina.