Inhibition of prostaglandin synthesis by indoprofen
Stygles, V.G.; Newton, J.F.; Hook, J.B.
Research Communications in Chemical Pathology and Pharmacology 18(2): 329-340
1977
ISSN/ISBN: 0034-5164 PMID: 411161 Document Number: 123525
Many non-steroidal anti-inflammatory, analgesic drugs appear to produce their effects by inhibiting prostaglandin synthesis. These investigations were undertaken to determine whether a new anti-inflammatory compound, indoprofen, inhibited prostaglandin synthesis in vitro when present in incubation medium or following systemic administration. The results indicated that indoprofen effectively inhibited prostaglandin synthesis in kidney and uterus. Indoprofen was equally effective as indomethacin and aspirin in inhibiting prostaglandin synthesis. The relative potency of the drug was intermediate between indomethacin and aspirin.