Efficacy of celecoxib on controlling irregular uterine bleeding secondary to Jadelle use

Buasang, K.; Taneepanichskul, S.

Journal of the Medical Association of Thailand 92(3): 301-307

2009


ISSN/ISBN: 0125-2208
PMID: 19301720
Document Number: 12341
To evaluate the efficacy of celecoxib and placebo for controlling irregular uterine bleeding in Jadelle users. Randomized double blind placebo controlled trial. Family Planning Clinic, King Chulalongkorn Memorial Hospital, Bangkok, Thailand. Forty Jadelle users with irregular bleeding were randomly allocated into two groups. Twenty users received celecoxib 200 mg once a day for five days and the other twenty users received the placebo in the same manner The participants were requested to maintain their daily record of bleeding, adverse effects, and satisfaction. The percentage of the subjects whom bleeding was stopped within 7 days after initial treatment was significantly higher in the celecoxib group than in the placebo group (70% vs. 0%; p < 0.001). The mean duration of bleeding-free interval was significantly longer in celecoxib than placebo group (24.0 +/- 1.65 days vs. 10.0 +/- 6.50 days; p < 0.001). The mean duration of bleeding days was significantly shorter in celecoxib than placebo group (5.0 +/- 1.65 vs. 19.0 +/- 6.50 days; p < 0.001). Patients satisfaction in celecoxib group was significantly higher than the placebo group (80% vs. 30%; p < 0.001). There was no detectable adverse effect in both groups. Celecoxib was more effective than placebo in the short-term control of irregular bleeding in Jadelle users. The mechanism of nonsteroidal anti-inflammatory drugs (NSAIDs) for the reduction of endometrial bleeding is likely from COX-2 inhibition.

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Efficacy of celecoxib on controlling irregular uterine bleeding secondary to Jadelle use