Inhibition of target cell mitosis as a measure of the cytostatic effects of activated macrophages on tumor target cells
Krahenbuhl, J.L.; Remington, J.S.
Cancer Research 37(11): 3912-3916
1977
ISSN/ISBN: 0008-5472 PMID: 908031 Document Number: 122766
Studies were done in vitro showing that activated macrophages inhibited mouse EMT-6 mammary tumor target cells from undergoing mitosis. With the use of target cells synchronized in the mitosis phase of the cell cycle, this manifestation of macrophage-mediated cytostatic effects was preceded by the complete inhibition of target cell DNA synthesis as measured by incorporation of [3H]thymidine.
Document emailed within 1 workday
Related Documents
Erb, P.; Grogg, D.; Troxler, M.; Kennedy, M.; Fluri, M. 1990: CD4+ T cell-mediated killing of MHC class II-positive antigen-presenting cells. I. Characterization of target cell recognition by in vivo or in vitro activated CD4+ killer T cells Journal of Immunology 144(3): 790-795Halloran, P.F.; Stubbs, M. 1979: Macrophage-alloantibody-target cell interactions. III. Stripping of antibody-coated cells by human macrophages Clinical and Experimental Immunology 38(3): 568-577
Holden, H.T.; Landolfo, S.; Herberman, R.B. 1977: T-cell-dependent reactivity against tumor-associated antigens on allogeneic target cells Transplantation Proceedings 9(1): 1149-1152
Sahin, A.; Vercamer, C.; Kaminski, A.; Fuchs, T.; Florin, A.; Hahne, J.C.; Mattot, V.; Pourtier-Manzanedo, A.; Pietsch, T.; Fafeur, V.ér.; Wernert, N. 2009: Dominant-negative inhibition of Ets 1 suppresses tumor growth, invasion and migration in rat C6 glioma cells and reveals differentially expressed Ets 1 target genes International Journal of Oncology 34(2): 377-389
Cichocki, T.; Zembala, M.; Ptak, W. 1975: The role of macrophages in the cytotoxic killing of tumour cells in vitro. II. the morphology and ultrastructure of target cell - macrophage interaction in vitro Pathologica 67: 971-972
Avantaggiati, M.L. 2013: Cancer metabolism as a therapeutic target: finding the right target(s) in the context of tumor heterogeneity, evolution, and metabolic plasticity Oncology 27(5): 474; 476-477
Moolten, F.L.; Capparell, N.J.; Cooperband, S.R. 1972: Antitumor effects of antibody-diphtheria toxin conjugates: use of hapten-coated tumor cells as an antigenic target Journal of the National Cancer Institute 49(4): 1057-1062
Ballas, Z.K.; Rasmussen, W. 1987: Lymphokine-activated killer (LAK) cells. III. Characterization of LAK precursors and susceptible target cells within the murine thymus Journal of Immunology 139(10): 3542-3549
Smirnova, M.N.; Bazanova, E.A. 1974: Macrophages as target cells in in vitro experiments on delayed hypersensitivity Vestnik Akademii Meditsinskikh Nauk SSSR 11: 14-16
Procyk, K.J.; Rippo, M.R.; Testi, R.; Hoffmann, F.; Parker, P.J.; Baccarini, M. 1999: Distinct mechanisms target stress and extracellular signal-activated kinase 1 and Jun N-terminal kinase during infection of macrophages with Salmonella Journal of Immunology 163(9): 4924-4930
Adams, D.O.; Marino, P.A. 1981: Evidence for a multistep mechanism of cytolysis by BCG-activated macrophages: the interrelationship between the capacity for cytolysis, target binding, and secretion of cytolytic factor Journal of Immunology 126(3): 981-987
Lichtenstein, A.K.; Ganz, T.; Nguyen, T.M.; Selsted, M.E.; Lehrer, R.I. 1988: Mechanism of target cytolysis by peptide defensins. Target cell metabolic activities, possibly involving endocytosis, are crucial for expression of cytotoxicity Journal of Immunology 140(8): 2686-2694
Lee, K.C.; La Posta, V.J. 1986: Differential expression of tumor target binding and cytolytic activities in bone marrow culture-derived macrophages Journal of the National Cancer Institute 77(6): 1287-1297
Gilmer, P.J.; McDevitt, H.O.; McConnell, H.M. 1978: Inhibition of specific effector T cell-target cell conjugates by cell plasma membranes Journal of Immunology 120(3): 774-776
Lavrovskiĭ, V.A.; Tikhonov, V.I.; Rubtsov, G.B.; Razvoretnev, V.A. 1976: Target cell production of substances modifying the degree of their lysis by immune lymphocytes and macrophages Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 12: 77-81
Millar, B.C.; Fielden, E.M.; Millar, J.L. 1978: Interpretation of survival-curve data for Chinese hamster cells, line V-79 using the multi-target, multi-target with initial slope, and alpha, beta equations International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine 33(6): 599-603
Pastoret, P.P.; Brochier, B.; Boulanger, D. 1995: Target and non-target effects of a recombinant vaccinia-rabies virus developed for fox vaccination against rabies Developments in Biological Standardization 84: 183-193
Hamada, I.; Kato, M.; Yamasaki, T.; Iwabuchi, K.; Watanabe, T.; Yamada, T.; Itoyama, S.; Ito, H.; Okada, K. 2002: Clinical effects of tumor-associated macrophages and dendritic cells on renal cell carcinoma Anticancer Research 22(6c): 4281-4284
Roveta, G.; Magrassi, L. 1984: Morphological characterization of lymphoid cells conjugates with scattered tumor target cells in organ imprints of Yoshida ascites bearing rats Bollettino della Societa Italiana di Biologia Sperimentale 60(12): 2365-2368
Giardina, S.L.; Anderson, S.K.; Sayers, T.J.; Chambers, W.H.; Palumbo, G.A.; Young, H.A.; Ortaldo, J.R. 1995: Selective loss of NK cytotoxicity in antisense NK-TR1 rat LGL cell lines. Abrogation of antibody-independent tumor and virus-infected target cell killing Journal of Immunology 154(1): 80-87