Histopathological evaluation of the inhibition of rat bladder carcinogenesis by 13-cis-retinoic acid
Squire, R.A.; Sporn, M.B.; Brown, C.C.; Smith, J.M.; Wenk, M.L.; Springer, S.
Cancer Research 37(8 Part 2): 2930-2936
1977
ISSN/ISBN: 0008-5472 PMID: 872120 Document Number: 122503
An objective system for histopathological and statistical evaluation of rat bladder lesions induced by the carcinogen, N-methyl-N-nitrosourea, is described. This system has been used to measure the inhibitory effects of 13-cis-retinoic acid on the development of bladder cancer in female Wistar/Lewis rats. 13-cis-Retinoic acid caused significant inhibition of development of both preneoplastic and neoplastic lesions in bladder epithelium.
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