The angiotensin i converting enzyme
Erdös, E.G.
Federation Proceedings 36(5): 1760-1765
1977
ISSN/ISBN: 0014-9446 PMID: 191298 Document Number: 122204
The angiotensin I converting enzyme (kininase II; peptidyl dipeptidase; EC3.4.15.1) has a dual function: it converts angiotensin I to angiotensin II and it inactivates bradykinin. Lung, kidney, guinea pig plasma and testicles are among the richest sources of the enzyme. Vascular endothelial cells and bursh borders of renal proximal tubular cells contain high concentrations of the enzyme. The availability of synthetic peptide inhibitors was a great help in establishing the function of converting enzyme in normal and pathological conditions.
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