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Glycine-receptors in the vertebrate central nervous system

DeFeudis, F.V.

Acta Physiologica Latino Americana 27(4): 131-145

1977

ISSN/ISBN: 0001-6764
PMID: 617561
Document Number: 121659
Evidence for the existence of glycine-receptors in the vertebrate central nervous system (CNS) has been reviewed and analyzed. Biochemical studies have supported iontophoretic findings that such receptors exist in several regions of the CNS. Subcellular studies on the displacement of 3H-strychnine binding by glycine and on the effects of strychnine on 3H-glycine binding have revealed that strychnine does not interact directly with glycine-receptors, lending support to studies performed in situ. Approaches toward glycine-receptors remain limited due to the inavailability of a specific glycine-antagonist.

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