Effects of the number of DNP groups on dinitrophenylated human serum albumin upon the induction of immunological memory for the dinitrophenyl determinant
Larralde, C.; Lagunoff, D.
Archivos de Investigacion Medica 8(3): 165-174
1977
ISSN/ISBN: 0066-6769 PMID: 72549 Document Number: 121598
Immunological memory to the DNP determinant is shown to be a positive correlate of the primary anti-DNP response and of the extent of DNP substitution in the priming antigen. Antigen dose-response curves for immunological memory first increase with antigen dose to reach a maximum and then decrease in the high dose region. Increasing the extent of DNP substitution in the priming antigen shifts the dose-response curves to lower antigen doses and promotes the antigen's ability to induce immunological memory to a level greater than that expected by its ability to induce a primary response. The findings are interpreted in terms of postulated effects of degree of DNP substitution on the binding of antigen to cell receptors.